Team	GS	W	G	V	P
1 Tampa Bay Rowdies Tampa Bay Rowdies	32	23	2	7	71
2 Phoenix Rising FC Phoenix Rising FC	32	20	7	5	67
3 El Paso Locomotive FC El Paso Locomotive FC	32	18	10	4	64
4 Louisville City FC Louisville City FC	32	18	7	7	61
5 Birmingham Legion FC Birmingham Legion FC	32	18	6	8	60
6 Charlotte Independence Charlotte Independence	32	18	5	9	59
7 Pittsburgh Riverhounds SC Pittsburgh Riverhounds SC	32	17	7	8	58
8 Miami FC Miami FC	32	16	6	10	54
9 Orange County SC Orange County SC	32	15	7	10	52
10 San Antonio FC San Antonio FC	32	14	10	8	52
11 Memphis 901 FC Memphis 901 FC	32	14	8	10	50
12 Colorado Springs Switchbacks FC Colorado Springs Switchbacks FC	32	13	10	9	49
13 San Diego Loyal SC San Diego Loyal SC	32	14	6	12	48
14 FC Tulsa FC Tulsa	32	14	5	13	47
15 Rio Grande Valley FC Rio Grande Valley FC	32	13	8	11	47
16 New Mexico United New Mexico United	32	12	10	10	46
17 Austin Bold Austin Bold	32	10	12	10	42
18 Hartford Athletic Hartford Athletic	32	12	5	15	41
19 Oakland Roots SC Oakland Roots SC	32	11	8	13	41
20 Ventura County FC Ventura County FC	32	11	6	15	39
21 Tacoma Defiance Tacoma Defiance	32	10	9	13	39
22 Charleston Battery Charleston Battery	32	10	7	15	37
23 OKC Energy FC OKC Energy FC	32	8	13	11	37
24 Sacramento Republic FC Sacramento Republic FC	32	8	12	12	36
25 Indy Eleven Indy Eleven	32	9	8	15	35
26 Atlanta United 2 Atlanta United 2	32	8	10	14	34
27 New York Red Bulls II New York Red Bulls II	32	7	7	18	28
28 Real Monarchs SLC Real Monarchs SLC	32	5	7	20	22
29 Las Vegas Lights FC Las Vegas Lights FC	32	6	3	23	21
30 Sporting Kansas City II Sporting Kansas City II	32	4	8	20	20

Louisville City FC - Sporting Kansas City II

Op 9 oktober 2021 gaat Louisville City FC de strijd aan met Sporting Kansas City II. De wedstrijd wordt afgetrapt om 23:30 en wordt gespeeld in de USA 2.